Sept. 13 (Thur.)

09:00-09:05 : Opening Ceremony
Welcome Speech:Okio Hino (Juntendo Univ. Faculty of Med)
09:05-10:35 : Session 1
Treatment with Rapalogs: State of the Art
Moderator :John Bissler (Univ. of Tennessee Health Sci. Center)
Mari Wataya-Kaneda (Osaka Univ.)
09:05-09:35 : David N Franz(Cincinnati Child. Hospital Med. Center)
mTOR inhibition as a disease-modifying therapy in tuberous sclerosis complex
09:35-10:05 : Mari Wataya-Kaneda(Osaka Univ.)
Sirolimus gel treatment for facial angiofibromas in tuberous Sclerosis Complex - Phase 3 and long-term clinical trial
10:05-10:20 : Lisa F Akiyama(Saint Louis Univ./SSM Cardinal Glennon Child. Hospital)
Efficacy and safety of everolimus treatment of refractory epilepsy in children with tuberous sclerosis complex
10:20-10:35 : Christoph Hertzberg(Vivantes Krankenhaus Neukölln)
Long-term Efficacy and Safety of Everolimus among Paediatric Patients with Tuberous Sclerosis Complex (TSC) and Treatment-Refractory Seizures: Final Analysis of the EXIST-3 Study
10:35-10:55 : Break
10:55-12:10 : Session 2
Beyond Rapalogs in TSC/LAM: Can We Eliminate Tumor Cells?
Moderator :Elizabeth P Henske (Brigham and Women's Hospital and Harvard Med. Sch.)
Toshiyuki Kobayashi (Juntendo Univ. Grad. Sch. Med.)
10:55-11:25 : Hongbing Zhang(Peking Union Med. College and Chinese Acad. Med. Sci.)
mTOR regulation of xCT in melanin synthesis and tumor development
11:25-11:55 : David J Kwiatkowski(Brigham and Women's Hospital and Harvard Med. Sch.)
Targeting transcription in TSC
11:55-12:10 : Jeanine D' Armiento(Columbia Univ.)
Novel mTOR-independent signaling pathways attenuating renal angiomyolipoma cell survival
12:10-12:25 : Break
12:25-13:15 : Luncheon Seminar
The progress of medical treatment for TSC in Japan
Chair:Yukitoshi Takahashi (Shizuoka Inst. Epilepsy and Neurol. Disorders)
Speaker:Tohru Okanishi (Seirei Hamamatsu General Hospital)
13:15-13:25 : Break
13:25-15:25 : Session 3
Seizures and Epilepsy in TSC: New insights, New Therapies
Moderator :Paolo Curatolo (Tor Vergata Univ. Hospital of Rome)
Ayataka Fujimoto (Seirei Hamamatsu General Hospital)
13:25-13:55 : Sergiusz Jozwiak(Warsaw Medical Univ.)
Advances in epilepsy treatment in TSC
13:55-14:25 : Lawrence S Hsieh(Yale Univ. Sch. of Med.)
Modeling epileptogenesis in TSC
14:25-14:55 : Joyce Y Wu(Univ. of California Los Angeles)
14:55-15:10 : Katarzyna Kotulska(The Child. Memorial Health Inst.)
Long term study of vigabatrin – associated white matter changes in TSC children with epilepsy
15:10-15:25 : Rima Nabbout(Paris Descartes Univ.)
Tuberous Sclerosis Complex (TSC) - Associated Epilepsy: Final Results from the TOSCA Study
15:25-15:40 : Break
15:40-17:40 : Session 4
TSC-associated neuropsychiatric disorders (TAND) – current concepts and management
Moderator :Julian Sampson (Cardiff Univ.)
Tohru Okanishi (Seirei Hamamatsu General Hospital)
15:40-16:25 : Petrus de Vries(Univ. of Cape Town)
An update on TSC-Associated Neuropsychiatric Disorders (TAND)
16:25-16:55 : Paolo Curatolo(Tor Vergata Univ. Hospital of Rome)
Autism in tuberous sclerosis: early developmental trajectories, potential biomarkers and treatment strategies
16:55-17:25 : Darcy A Krueger(Cincinnati Child. Hospital Med. Center)
Understanding and targeting TSC-associated neuropsychiatric disorder (TAND) throughout the lifespan of tuberous sclerosis
17:25-17:40 : Tanjala T Gipson(Univ. of Tennessee Health Sci. Center)
Treating Aggression in Tuberous Sclerosis Complex
17:40-18:00 : Break & Movement
18:00-20:00 : Reception

Sept. 14 (Fri.)

08:30-10:00 : Session 5
Cell culture and animal models of TSC/LAM – new insights
Moderator :Jane J Yu (Univ. of Cincinnati)
Yo Niida(Kanazawa Med. Univ.)
08:30-09:00 : Ravi Jagasia(F. Hoffmann-La Roche Ltd,)
mTORC1 controls neurodevelopment and synaptic plasticity in a time-dependent manner in cell models of tuberous sclerosis
09:00-09:30 : Elizabeth P Henske(Brigham and Women's Hospital and Harvard Med. Sch.)
Targeting TSC with Immunotherapy: Lessons from Immunocompetent Mouse Models
09:30-09:45 : Toshiyuki Kobayashi(Juntendo Univ. Grad. Sch. Med.)
Exploring downstream pathways of Erc/Msln as therapeutic targets of TSC - a quarter-century of TSC research in Dr. Hino’s Lab.
09:45-10:00 : Wei Shi(The Saban Research Institute)
Establishment of Tsc2-null mouse lung mesenchymal progenitor cell lines
10:00-10:35 : Break
10:35-12:20 : Session 6
Biology and Pathogenesis of TSC/LAM
Moderator :David J Kwiatkowski (Brigham and Women's Hospital and Harvard Med. Sch.)
Kuniaki Seyama(Juntendo Univ. Faculty of Med.)
10:35-11:05 : Kuniaki Seyama(Juntendo Univ. Faculty of Med.)
Biology and Pathogenesis of LAM from a clinician's view
11:05-11:35 : Jane J Yu(Univ. of Cincinnati)
11:35-12:05 : Peter B Crino(Univ. of Maryland Sch. of Med.)
12:05-12:20 : Anna M Larson(Massachusetts General Hospital)
Malignancy in tuberous sclerosis complex
12:20-12:35 : Break
12:35-13:25 : Luncheon Seminar
State-of-the-art therapy for angiofibromas and other skin lesions in TSC patients
Chair:Mari Wataya-Kaneda (Osaka Univ.)
Speaker:Adelaide A Hebert (Univ. of Texas Health Sci. Center at Houston)
13:25-13:35 : Break
13:35-15:05 : Session 7
Basic science studies relevant to TSC/LAM
Moderator :Peter B Crino (Univ. of Maryland Sch. of Med.)
Yuji Yamamoto (Tokyo Univ. of Agriculture)
13:35-14:05 : Brendan D Manning(Harvard T.H. Chan Sch. Public Health)
Understanding and treating TSC through mechanistic insights from basic science
14:05-14:20 : Atsushi Sato(Univ. of Tokyo)
Autistic-like behavioral deficits are severer in Tsc2 than Tsc1 haploinsufficiency in mouse models of TSC
14:20-14:35 : Oded Volovelsky(Hadassah Hebrew Univ. Med. Center)
Tsc1 deletion in nephron progenitor cells leads to accelerated nephrogenesis
14:35-14:50 : Yuji Yamamoto(Tokyo Univ. of Agriculture)
TSC2 is methylated on Arg1457 and Arg1459
14:50-15:05 : Kathrin Thedieck(Univ. of Groningen)
Lysosomal tethering of the TSC complex
15:05-15:20 : Break
15:20-16:35 : Session 8
Advances with Registries and Guidelines
Moderator :Martina Bebin (Univ. of Alabama at Birmingham)
Masashi Mizuguchi (Univ. of Tokyo)
15:20-15:50 : Nishant Gupta(Univ. of Cincinnati)
An update on the natural history, diagnosis, and management of LAM
15:50-16:20 : J Chris Kingswood(Royal Sussex County Hospital)
TOSCA–TuberOus SClerosis registry to increAse disease awareness: Final Analysis Exploring Clinical Manifestations Associated with Tuberous Sclerosis Complex in 2211 Patients
16:20-16:35 : Clara WT Chung(Sydney Child. Hospital and Univ. of New South Wales)
The effects of a multidisciplinary clinic on the diagnosis and management of tuberous sclerosis complex – an Australian experience
16:35-17:00 : Break & Movement
17:00-19:00 : Poster Session & Evening Buffet

Sept. 15 (Sat.)

08:30-10:00 : Session 9
Preventive Approaches to Improve QOL
Moderator :Darcy A Krueger (Cincinnati Child. Hospital Med. Center)
Masaya Kubota (National Center for Child Health and Develop.)
08:30-09:00 : Martina Bebin(Univ. of Alabama at Birmingham)
09:00-09:30 : Sean Kennedy(Sydney Child. Hospital and Univ. of New South Wales)
09:30-09:45 : Denise L Chan(Sydney Child. Hospital and Univ. of New South Wales)
TSC neuroradiological markers, epilepsy and cognitive outcomes at 5 years of age
09:45-10:05 : Break
10:05-11:50 : Session 10
Towards New Era of Living with TSC
Moderator :J Chris Kingswood (Royal Sussex County Hospital)
Okio Hino (Juntendo Univ. Faculty of Med.)
10:05-10:20 : Anna C Jansen(Vrije Universiteit Brussel)
Top 15 research priorities in tuberous sclerosis complex
10:20-10:50 : Hope Northrup(Univ. of Texas Health Sci. Center at Houston)
2018 Updates to the TSC Diagnostic Criteria and Surveillance and Management Recommendations
10:50-11:20 : John Bissler(Univ. of Tennessee Health Sci. Center)
11:20-11:50 : Julian Sampson(Cardiff Univ.)
Everolimus and neurocognition in tuberous sclerosis: findings from the TRON clinical trial
11:50-12:05 : Break
12:05-12:55 : Luncheon Seminar
The molecular logic of the TSC-mTOR signaling network
Chair:Kathrin Thedieck (Univ. of Groningen)
Speaker:Brendan Manning (Harvard T.H. Chan Sch. Public Health)
12:55-13:05 : Break
13:05-17:30 : Panel Discussion & TSC Family’s Events
Meet the Experts
13:05-14:25 : Early infancy and seizure management in TSC
Panelists: Darcy Krueger, Joyce Y Wu, Ayataka Fujimoto, Hidenori Sugano (Juntendo Univ. Faculty of Med.)
14:35-15:55 : TAND during early through late childhood
Panelists: Petrus deVries, Darcy A Krueger, Anna C Jansen, Mitsugu Uematsu (Tohoku Univ. Sch. Med.), Tohru Okanishi
16:05-17:25 : Management of TSC angiomyolipomas and LAM
Panelists: John Bissler, Nishant Gupta, Kuniaki Seyama, Ryohei Kuwatsuru (Juntendo Univ. Faculty of Med.)
17:30 : Closing Ceremony
Speech:Okio Hino (Juntendo Univ. Faculty of Med)